Interpreting Conjugated Bilirubin Levels in Newborns

The predictive value of first day bilirubin levels for early discharged newborns.

Objective: Early discharge of newborns is essential because of social, economic an medical reasons in our area, but it increases readmission rates especially for hyperbilirubinemia. Hence, predicting the high risk neonates for subsequent hyperbilirubinemia is required. This study was designed to investigate which level of total serum bilirubin (TSB) at the first day could be used to predict hyp...

Does conjugated bilirubin displace unconjugated bilirubin from albumin.

Porphyrin-induced photooxidation of conjugated bilirubin.

Visible light irradiation of 18 microM bilirubin ditaurate (BR-DT) at pH 7.0 for 30 min showed a 10% decrease in absorbance at 445 nm. When the reaction was carried out in the presence of a trace amount of uroporphyrin (UP), the spectrum of BR-DT disappeared without a concomitant formation of biliverdin. Photooxidation products were confirmed to be dipyrrole-containing compounds. Photo-bleachin...

Outcomes among newborns with total serum bilirubin levels of 25 mg per deciliter or more.

BACKGROUND The neurodevelopmental risks associated with high total serum bilirubin levels in newborns are not well defined. METHODS We identified 140 infants with neonatal total serum bilirubin levels of at least 25 mg per deciliter (428 micromol per liter) and 419 randomly selected controls from a cohort of 106,627 term and near-term infants born from 1995 through 1998 in Kaiser Permanente h...

Determination of unbound bilirubin in the serum of newborns.

An enzymatic assay is described for non-albuminbound bilirubin in the serum of newborn infants. Unbound bilirubin is oxidized to colorless compounds by ethyl hydroperoxide in the presence of horseradish peroxidase (EC 1.11.1.7), while albumin-bound bilirubin is protected from oxidation. Because the equilibrium between albumin and bilirubin occurs rapidly, the oxidation step is rate limiting, an...